I am 68, I took one anastrozole pill and my whole right hand froze up with trigger fingers. I was switched to letrozole, 2.5mil. I choose to cut the pills in half and take them Monday, Wednesday and Fridays. There was a trial done in 2010 where there was no difference in taking it like that and at a lower dose then the way it was being prescribed. I feel it is a compromise on my part. I've been on it for 3 weeks and so far no side effects. The half life of letrozole is 48 hours so I don't know why you should take it every day. I also take natural AIs, grape seed extract, DIM and a few others. I also take a calcium supplement and MSM 6000 mil for any joint pain. I gave up drinking any alcohol and only eat food we cook at home. I had a low oncotype score 5 with a reoccance rate of 3 percent. Everyone needs to do what they can live with