I recommend working with your doctor and getting blood work done so you will know exactly where you stand in regard to the various vitamin B levels. I have neuropathy with no known cause. Symptoms are numbness and tingling in my feet. After my diagnosis, I noticed at various times it seemed worse. First time was caused by taking atorvastatin. Stopped that med and I was much improved (along with a bunch of other issues!). More recently my neurologist saw that my Vit. B6 level was very elevated. He had me stop taking my multivitamin and fish oil tabs which I had been on for years. My neuropathy is way better. I agree with a previous comment that taking specific supplements for your individual needs is the best way to go. This way if you notice changes in your health it is easier to pinpoint the source.