There's a lot to unpack to fully answer your questions and concerns about your sister. If she currently is fighting a lung infection, she would most likely not have the stamina to take a trip. At least that would be my experience. Many people with bronchiectasis routinely nebulize twice a day, and the nebulizer machine is rather large and heavy and loud. They do make small portable units that are great for traveling. And then there is the cleaning and sterilizing of your nebulizer cups that must be done daily. I do travel a bit, but there is much more to think about now. Things like hot/boiling water, what kind of shower head does the hotel bathroom have, being in close quarters with people indoors, etc. It can feel overwhelming and isolating to live with this diagnosis, but with time and determination it is possible to adjust and create a good "new normal". I think it is wonderful that you wish to support your sister and this site contains a wealth of information and ideas that could be helpful for both of you. You've come to the right place!