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Decide against aromatase inhibitors?
Breast Cancer | Last Active: Aug 27 10:53am | Replies (124)Comment receiving replies
As I get concerned about various issues, I am worried that a side effect of Exemestane is that it puts a permanent block on metabolizing any estrogen.
I think that if I have an allergic reaction to Exemestane in any way, that allergic reaction will be permanent because of permanent estrogen blockage.
I have had allergic reactions to most meds. given me in the past 3 years….
Replies to "As I get concerned about various issues, I am worried that a side effect of Exemestane..."
Your body produces aromatase everyday so we have to continue taking exemestane to block newly produced aromatase. Once you stop exemestane your body will eventually begin produce estrogen from new aromatase. I’m not quite sure what happens to the blocked aromatase. I read somewhere that taking it 3 times a week is non inferior to taking every day and side effects are less severe. My cancer is almost 100% er+ and I didn’t have chemo, so AIs are my best chance to prevent recurrence. Give it a try. You can always stop it if the side effects are too much.
I found this out through web search.Key Points
-Permanent Binding: Exemestane binds irreversibly to aromatase, but this does not mean the enzyme remains inactive forever.
-Resumption of Function: After discontinuation, aromatase can regain its activity, leading to a potential increase in estrogen levels over time.
I will ask my oncologist about this to confirm.
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I am Er&PR pos Her2-Neg Ki67-10% brca Neg Stage 1 1.2cm
lumpectomy done 7/29 clean margins Onco score 3
turned 70 in Dec I meet w radiologist to discuss treatment
I also have to meet oncologist who’s going to try and push hormone receptors which I am NOT interested! hearing every side effect is horror