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gemini1956 avatar

Clofazamine and rifampacin

MAC & Bronchiectasis | Last Active: Sep 2, 2025 | Replies (15)

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I was on Rifampin, ethambutol and clofazimine from 4/23 to 6/24 ( 15 mos.) I could not tolerate the azithromycin. My skin looked tan and still does- but not as much. My brown spots got darker. I am now culture negative for both MAC and M. abscesses. Had been positive for both. I do wonder if the fact that I still have Clofazimine in my body (from the discoloration) is having a protective effect against the bad bugs.

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Replies to "I was on Rifampin, ethambutol and clofazimine from 4/23 to 6/24 ( 15 mos.) I could..."

Thank you for your positive feedback. You raise an interesting point regarding the colour (the dye) possibly having a ‘protective’ effect. It is common, I hear, for the tanned effect to last months or years before dye leaves the soft tissues of the body. Sadly, delving into the ‘net for images of Clofazamine effects only enabled me to see the horrific, worst cases - to the extent that I had sleepless nights and continue to fret. My partner said “Marianne, you’re only going to see ‘bad’ examples of adverse side effects of any drug - ‘ordinary’ images of side effects of Clofazamine are never put out for viewing”! I used to be a ‘can do, will do, must do’ sort of person but the anxiety I’ve felt about, especially, having to start on such a high dose of Clofazamine (200 mg) AND Rifampacin alongside the other 3 has been personality changing. Clofazamine has been, I understand, banned by the FDA except ‘“off licence” so there must be valid reasons for this decision. Here in the UK it is still widely prescribed/used in most NTM/MAC treatment regimes.