I have a love/hate relationship with prednisone. When my kidneys failed 5 years ago it saved my life. I was on high doses to begin with and then tapered down. The prednisone put my minimal change disease in remission… then I started weaning off and began having excruciating pain all over – I believed it to be from the prednisone withdrawal…. then I had a relapse of my kidney disease, again helped by higher doses of prednisone… then began to wean again… and then the pain again… ended up working with endocrinology to change over to hydrocortisone and taper that VERY slowly as I had been on the prednisone long enough to now have secondary adrenal insufficiency. I was exhausted and still in pain after that. I was diagnosed then with spondylitis and take 5 mg daily to help keep that and my kidney disease at bay. I hate taking it but every time I taper below 5 things get worse for me. At 5 mgs my side effects are not insignificant but are tolerable mostly – I have gained 65 lbs., have a puffy moon face and neck, thin sin, trouble sleeping, anxiety, bruising, irritability, am ravenous… at the higher doses I become much puffier, hungrier, angrier, anxious, sweat a lot, have really bad hot flashes. And though my bone density scans come back normal I have broken my ankle doing absolutely nothing and have had 2 teeth break off at the roots and needs implants.Good luck!