Am following this important subject about OA and safest drug. Keep reading that a majority of people are also, very afraid of these drugs. A summary I read was written that 'while they help for a time' going forward there are none that keep helping. This is such a great website and keep reading with the hope that I will learn something else other than to be so terrified - as the OA I have has made my hands almost impossible to use or move as are all swollen and painful. Wait till noon for 2nd dose of Tylenol to lessen the symptoms. 5 pm even better but not like I am pain free. Even walking with a cane, hurts - handle so hard as well on the can. At the same time, need a hip replacement surgery. Can't have that when my upper body is under siege. Wishing all in the same boat, luck with this, have to keep hoping and finding answers.