Hi @surftohealth88 : I am sorry to hear that the final pathaolgy report upgraded the grade of the cancer but was inconclusive about the stage, though your husband's recent negative PSMA PET scan is somewhat rassrruing (even though we know this tool is not 100% perfect in every scenario).

With repect to second opinion on patholgy, the gold standard is the Epstein Lab of John Hopkins which has done thousands and has established protocols for the transfer of tissue specimens and patholgy slides. You may want to look into that.

I also recommend Parick Walsh's book entitled "Gude to Surving Prostate Cancer" to everyone since it is the most comprehensive, and most undertandable with each chatpter starting with a summary, It has been updated recently. As you well know Dr Walsh of John Hopkins is the father of radical prostatectomy, is a big believer of second opinion on pthology, and Epestein is the pathologists whom he recommends.