Connect
← Return to Brinsupri (aka Brensocatib)
Discussion
Comment receiving replies
I must have read the same post. Someone commented (and my pulmonologist confirmed) that it may be have been due to Papillon–Lefèvre syndrome (PLS) is a very rare inherited disorder caused by mutations in the CTSC gene.
It is characterized by:
Thickened, scaly skin on the palms and soles (palmoplantar keratoderma)
Severe early-onset gum disease (periodontitis)
Premature loss of both baby and adult teeth
It usually begins in early childhood and is linked to a deficiency of the enzyme cathepsin C (DPP1).
When taking Brinsupri regular dental checks are imperative, every 3-6 months.
Replies to "I must have read the same post. Someone commented (and my pulmonologist confirmed) that it may..."
Thanks for that comment Scoop.
(Sigh) "That" page immediately posted a boogy man story in response to a new drug therapy that could be a game changer for many people. Yes, it has side effects as do all drugs. We all need to read, ask questions and educate ourselves before taking something one person posted at face value. Follow the science.
So are you saying that this very rare genetic disorder was the cause of the one or two cases? That seems highly coincidental and unlikely. If it is a known possible side effect (gum disease) and they were in the trial it seems obvious to be caused by Brensocatib.
Hi Scoop
Just checked the LM post and the fellow who was losing all his teeth did NOT have PLS apparently. He has posted that he doesn't have that disease....so there may be risks to dental health to consider.
Connect
Thank you, Scoop. Appreciate that.