← Return to Brinsupri (aka Brensocatib)

Discussion
scoop avatar

Brinsupri (aka Brensocatib)

MAC & Bronchiectasis | Last Active: 2 days ago | Replies (143)

Comment receiving replies
Profile picture for narelled23 @narelled23

I have heard via the Lung Matters Facebook page that some (1 or 2) people on the trial have had to have all their teeth pulled after using this drug. Just something to be aware of...as a side effect.

Jump to this post


Replies to "I have heard via the Lung Matters Facebook page that some (1 or 2) people on..."

I must have read the same post. Someone commented (and my pulmonologist confirmed) that it may be have been due to Papillon–Lefèvre syndrome (PLS) is a very rare inherited disorder caused by mutations in the CTSC gene.

It is characterized by:
Thickened, scaly skin on the palms and soles (palmoplantar keratoderma)
Severe early-onset gum disease (periodontitis)
Premature loss of both baby and adult teeth
It usually begins in early childhood and is linked to a deficiency of the enzyme cathepsin C (DPP1).

When taking Brinsupri regular dental checks are imperative, every 3-6 months.