Ondasetron (Zofran) causes constipation, something I've really been struggling with after Enhertu infusions. It comes on about two days after chemo and lasts well into the 7th day. Have been trying everything to resolve it, but without much luck. I swear the constipation is causing the nausea and told my oncologist so.
Senna pills before bedtime and stool softeners whenever sort of help, but there is a still a full and very uncomfortable feeling under my diaphragm. Burping and gas is frequent and annoying. I have to be careful not to take too much senna for fear of getting diarrhea. Tried Restoralax, but that kept me up all night feeling nauseous. Ginger tea helps a little bit but is short lived. I also mix in a bit of lemon juice and honey to make it palatable. As for dosage of Zofran, the oncologist cut it back to half a pill (I don't remember the mg of it) to avert constipation, but that didn't help. Just saying.