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gemini1956 avatar

Clofazamine and rifampacin

MAC & Bronchiectasis | Last Active: Sep 2, 2025 | Replies (15)

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Gemini 1956 I was on Clofazimine for about eight months. I was very nervous about taking it but for me was the easiest of all the MAC medications. I did have darkening of skin but that wasn’t a problem as a I got a lot of compliments on my tan and questions about where I had vacationed. The only negative I experienced was itching. I used Gold Balm anti-itch cream all over after a shower and that helped a lot. I would not hesitate to take it again if necessary.

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Replies to "Gemini 1956 I was on Clofazimine for about eight months. I was very nervous about taking..."

Hi Ivalenti, thanks, so much, for your reply - it’s very reassuring.

I already have quite tanned skin - my skin is olive/sallow colour in the winter but I tan very easily, without sunbathing, during summer months- even in Uk (where I live). I also love the sunshine and have a holiday in Greek Islands booked for last week of September. Then my partner and I are heading off to Spain for 5-6 weeks from early November. So I’m worried because on clofazamine, I understand you have to avoid the sun or use total sunblock. I’m also concerned about hyperpigmentation which I understand can be a significant side effect (not just Clofazamine ‘tan’). This can take months or years to be reversed. Rarer in Caucasian population than in Asian communities but, nonetheless, it can happen. I’ve seen some photos of patients affected and I am still rigid with anxiety - not, by far, my normal effervescent self. Im wondering if I should just postpone Clofazamine and Rifampcin (due to start that next week) until the middle of December (when I’m home from travels). I’m aware that some of the worst cases of Clofazamine (and Rifampicin) skin problems do leave patients with a real depression. I really do not want that - for me or my partner, or our family and friends. I’m normally such a buoyant, happy soul but the concerns over these 2 drugs are affecting my equilibrium so much right now. I’m coping very well with ethambutol, azithromycin and amakacin iv.

Thanks again for your positive story. 🙏🙏