I have psoriatic arthritis, so I have both the arthritis and rash. I think I had it most of my lift and didn't know it because it was very mild when I was young. Once it hit menopause, my psoriasis exploded.

I tried all the usual things, UVB light treatments, clobetasol (which wasn't enough for almost my entire body), changing diet, and nothing was helping, so I started Humira. It took quite a while to work, but after about a year and 1/2 or so, I was about 75 to 80% clear. I did have many problems with my pharmacy, though, and ended up getting late doses and missed doses. At one point, I had nothing for about 2 months, so my Doctor at the time suggested I try Consentyx. Well, my pharmacy and insurer denied me for Cosentyx and said I had to try Skyrizi, so I tried that. Apparently, Skyrizi is very successful for many people, but not me, unfortunately. Both my skin and joints went completely downhill while taking it.

Then I had go back to a Rheumatologist because my knee got so inflamed, and had me go back on Humira while adding methotrexate. That worked a bit better, but at one point, she had me take the Humira every 10 days rather than every 14 days. I did that for quite a few months until my pharmacy suddenly made me stop. It figured because the combo of Humira every 10 days along with methotrexate (even though I had awful side effects from the methotrexate) worked the best. I was almost completely clear of my rash once my pharmacy stopped me from taking it every 10 days. Back to every 14 days wasn't working as well, and my side effects from methotrexate were getting unbearable, so I stopped it for about 6 months.

Then at one point, my pharmacy stopped providing Humira all together, so I had to switch again. My Doc and I chose a biosimilar, but it didn't work nearly as well for me.

I have also since completely stopped methotrexate, again due to the side effects. At one point I tried the injectable format instead of the pills because my Doc said some people do better on the injections. It didn't seem to matter for me, though.'

Now, as of 4 or 5 months ago, I've been taking Cosentyx. My pharmacy allowed it this time, I guess because of the failure of Skyrizi and the Humira biosimilar. It has not been working yet and my skin has been getting worse again. The itching had come back full force, though my joints aren't too bad. Maybe it works better for my joints than my skin. At last month's office visit, my Doc and I decided to try the higher dose of Cosentyx (300mg instead of 150mg per month), so I will see how that goes. I am due to my first dose of the 300 mg in about 2 weeks.

There are many biologic options available that target different proteins in the body, so if one doesn't work, there are others to try. It can be frustrating, though, because the results usually don't happen right away. Taking methotrexate along with biologics can help alot if you can tolerate the side effects. Not everyone gets side effects, either.