Cribriform refers to a specific growth pattern of cancer cells characterized by the formation of multiple, small, hole-like structures (lumina) within a solid mass of cells. This pattern is considered an indicator of aggressive cancer and is often associated with higher Gleason scores and poorer outcomes.

Cribriform patterns are linked to increased risks of metastasis (cancer spreading to other parts of the body) and disease-specific death, particularly in men with Gleason score 7 (3+4) prostate cancer.