*sigh, could be ...but he had only one 4+3 out of 14 and this upgrade happened in that EXACT spot where 4+3 was found during biopsy. Since biopsy was actually of so called "saturation" kind sampling in that single small lesion that he had on the right side of a prostate, I do not think that anything was "missed". Urologist even pointed to all cores taken in extreme close proximity around that 4+3 core which had 3+3 or LESS changes. 4+5 was found now in that EXACT small spot ! TOTAL tumor size is 6-10% of a gland, nothing was found in 90% - 94% of the gland with detailed examination of the whole gland taken out. So it is not like they all of the sudden found new spot that needle missed on a left side or different location. His whole tumor is that tiny spot but sooooo aggressive that it is mind boggling 🤯 ! That is for you cribriform and IDC ! And I just want to jump out of my skin when patients with indolent PC here start giving advice to cribriform and IDC patients to "just do surveillance" or "try focal therapy" as a blanket advice. 😨