Are there data on PEA for helping nerve pain? What dose? I have much nerve pain from a compressed femeral nerve at L4-5. I've had 2 epidural cortisone injection, and after a terrible 4-day flare from the last injection, am finally getting improvement such that I can walk short distances- yea! But I still have pain throughout my leg and in particular a numbness and burning on my lower leg. I suspect that will take months if not years for that to recover- but anything to reduce that nerve pain would be helpful. I have not been able to see what dose of PEA is used without a lot more digging- but it sounds like something worth looking into

AI summary- makes it sound like the best thing since blue cheese- but none of my doctors have mentioned it:
Modulation of the endocannabinoid system: PEA interacts with cannabinoid receptors (CB1 and CB2) and the transient receptor potential vanilloid type-1 (TRPV1) channels, influencing pain signaling pathways.
Interaction with PPAR-alpha: PEA activates the peroxisome proliferator-activated receptor alpha (PPAR-α), which plays a role in regulating inflammation and pain.
Reduction of neuroinflammation: PEA reduces mast cell migration and degranulation and decreases the over-activation of glial cells (microglia and astrocytes), which contribute to inflammation and pain sensitization.

2025 Review: https://link.springer.com/article/10.1007/s40122-024-00685-4