I take mine in the morning, but I am not on a low dose. I am on 25 mg. I found I could not sleep taking it, however a low dose, like 4.5 mg might not have that effect.

For me, 1.5 mg initially made me quite sleepy so took it at night as advised. After two weeks, it gave insomnia so I now have approval to take it in the morning.

I am up to 4.5 mg now so I take 3 mg first thing and then 1.5 about noon. That seems to give me better energy throughout the day than taking it all at once.

@arichards3 I found taking 1.5 mg ldn at night interrupted my sleep, so I take it in the morning now. I am taking ldn for my Long Covid constant head pressure and fatigue. Good luck!