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Decide against aromatase inhibitors?

Breast Cancer | Last Active: Aug 27 10:53am | Replies (124)

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@timely
Like you I had side effects with both anastrozole and letrozole. I was on anastrozole for a year until my fingers became so stiff that I couldn’t hold on to any object. The joint and muscle pain did get better though. Moved on to Exemestane. Everything was fine until I had mastectomy. I had to do warm compression to get rid of hematoma. Combination of that and Exemestane gave me petechiea. So my onco prescribed Letrozole. It’s the worst! After only three months and several aura headaches I had a full blown migraine that woke me up at night. So now I’m back on exemestane. The first week I took it every other day for my system to adjust. The second week I took it for two consecutive days then off one day. So far so good. I plan to stay on it like for a while. You might want to ease your body into it to see if it works better. Unlike Anastrozole and Letrozole, half life of Exemestane is 24 hours. Since the drug leave your body faster, maybe the side effects are less severe. If you decide to try it, please let me know how it turns out. Make sure you do light exercise like walking every day. That helps a lot with joint pains. Good luck with Exemestane. Hugs.

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Replies to "@timely Like you I had side effects with both anastrozole and letrozole. I was on anastrozole..."

As I get concerned about various issues, I am worried that a side effect of Exemestane is that it puts a permanent block on metabolizing any estrogen.

I think that if I have an allergic reaction to Exemestane in any way, that allergic reaction will be permanent because of permanent estrogen blockage.

I have had allergic reactions to most meds. given me in the past 3 years….