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Decide against aromatase inhibitors?

Breast Cancer | Last Active: Aug 27 10:53am | Replies (124)

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I tried Breckinridge Letrozole and because of extreme total hip pain at the 2 year point, then tried Accord Letrozole and lasted 4 months on that till my leg muscles would just give out.

Each manufacturer adds different additives to their products.
Additives add to the problems.

I am off Letrozole til Oct and have to decide whether to take Exemestane.
I am 77.
Can’t take Anastrozole as both legs gave out after one tablet and pulse went up to 150 the next day.

Muscles in both legs above and below the knees just gave out…

I just do not want any more side effects…

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To everyone taking hormone receptor drugs God Bless you ALL!!!!!!! Every Scientist, Drug Company every Oncologist Dr that prescribes should be CONCERNED about all of the known Facts— the miserable side effects!!!! the hormone receptor drugs that are offered how are they helpful when there are proven horror side effects in every one of them what percentage of ppl taking them do not get breast cancer er back? How is it they have not found BETTER more Natural less toxic side effects in 2025!!!!! This scares me what is the cancer medical field doing about this?

@timely
Like you I had side effects with both anastrozole and letrozole. I was on anastrozole for a year until my fingers became so stiff that I couldn’t hold on to any object. The joint and muscle pain did get better though. Moved on to Exemestane. Everything was fine until I had mastectomy. I had to do warm compression to get rid of hematoma. Combination of that and Exemestane gave me petechiea. So my onco prescribed Letrozole. It’s the worst! After only three months and several aura headaches I had a full blown migraine that woke me up at night. So now I’m back on exemestane. The first week I took it every other day for my system to adjust. The second week I took it for two consecutive days then off one day. So far so good. I plan to stay on it like for a while. You might want to ease your body into it to see if it works better. Unlike Anastrozole and Letrozole, half life of Exemestane is 24 hours. Since the drug leave your body faster, maybe the side effects are less severe. If you decide to try it, please let me know how it turns out. Make sure you do light exercise like walking every day. That helps a lot with joint pains. Good luck with Exemestane. Hugs.