I, too, am on a beta blocker and med for essentially failed ablations. Been on Tymlos for 9 months, it definitely causes an increased heart rate for about 45 minutes a little while after I inject. I hate that but I just get through it, try to stay busy and not dwell. That’s why I inject in the morning instead of nighttime. It’s the only side effect I have except for the slight abdominal weight gain which some other ppl have mentioned on this site. It is helping my bones so I’ll put up with it until I’m finished.