In 2021 after Pirads 5 MRI, I had a 3+4 (less than 5% was 4) that slides regraded by Hopkins said just 3+3, and 4 was not apparent. I spent next two years taking supplements to see if it helps. But in 2023 at Mayo MRI the lesion was smaller or tiny now, but on biopsy the 3 was gone and just the small 4 was left, making mine a tiny 4+4. So worse grading than yours technically but anyway it was a 3+4 that supplements killed the 3.

Tulsa Pro easily reaches transition zones.

Here is my long story
https://connect.mayoclinic.org/discussion/tulsa-pro-initial-experience/
which got many replies over 2 years, but my info is in there.