Upon switching from Letrozole to Exemestane, my oncologist suggested taking the lowest dose every OTHER day…which has worked entirely better. I still get occasional hot flashes, but the leg cramps, bone pain, mood crazy states seem to be gone. Well…mood is always an issue, but it may come from life these days; who can tell?! Letrozole was hell for me, as was another I’ve forgotten. 4 more years of Exemestane does seem possible at this new dose pattern. Don’t hesitate to change when your symptoms interrupt your life like that!!