Large cribriform can be resilient to radiation in some cases and they are very aggressive. Your Decipher is very high. My husband had similar case and we opted for prostatectomy after consultations with both the surgeon and radiation specialist. Since high decipher and cribriform point to high aggressiveness of the cancer there is a possibility of recurrence and you can irradiate particular region only once. We wanted to have that second option available if there is any BCR in the future.