All of this information is so helpful. The comments and replies and investigation I so appreciate. I am in the middle of trying to decide whether to convince my pulmonologist to pursue the brensocatib. I definitely fit the category of 2 or more exacerbations a year with high neutrophil count; the airway clearance nebulizing done regularly and daily is so time consuming. I look for ward to following all your future info. Keep it coming.