As with everything else with prostate cancer side effects from ADT vary from person to person.

Even though I’ve been on it for nine years I’ve had never had a fatigue problem, but I have a terrible, hot flash problem.

I also never had depression from it and never gained weight from it, But many do.

The loss of muscles, The weakening of bones and Some cardiovascular problems affect almost everybody. Brain fog is another issue that only affects some people, And usually requires longer term use of ADT.