← Return to Trintellix (vortioxetine) for Major Depression or possibly Anxiety.

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I was on Trintellex for approximately 3 years after my previous medications, sertraline and Wellbutrin stopped working and also had two rounds of TMS.
I’ve suffered major depression and anxiety my entire life, I’m 70 now. I also have been taking Xanax for 30 years which I continue doing with a small dose of lamictal to help stabilize my mood. No more antidepressants for me.
Trintellex was awful for me, not only did it not work it made me very nauseous. I would never take it again, I believe it actually made my depression worse. I hope you have a better response. Good luck yo you.

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Replies to "I was on Trintellex for approximately 3 years after my previous medications, sertraline and Wellbutrin stopped..."

I am confused. You suffer from major depression and anxiety and in the same breath you say no more antidepressants for you.
From someone who is 74 and also suffer from major depression that makes no sense. I take Zoloft combined with Wellbutrin and Buspar and have been taking it for thirty years. I also take clonazepam and unlike you I have a very enjoyable life.
I can’t imagine what it must be like to be in a major depressive state and resign yourself to that for the rest of your life.
All I can say is good luck to you. I wouldn’t wish that on my worst enemy. I also feel sorry for your loved ones. I can’t imagine what they must be going through.
The shame is depression is treatable and yet you refuse treatment.

We're all so different when it comes to being guinea pigs for Big Pharma. I've been doing well on Depakote, while lamictal did nothing but increase my manic episodes. I've been taking Trintellex 20mg for a little over a week, and so far it's making me a bit woozy and somewhat sedated (but definitely drugged), and hopefully will help me out of major depression. I took CBD gummies (non THC) last night and had the first good night's sleep in weeks. I was evaluated for TMS sessions two weeks ago, but I really wish I could find a doctor who would prescribe a lousy 0.5mg or even 0.25mg of either alprazolam or clonazapam. I did well taking it only as needed for anxiety attacks and rare but horrible panic attacks. Even prescribing doctors seem to be tapering their patients off Benzos completely. At my age, and over the decades I've been taking them only as prescribed, it really sucks that we have such a crappy, expensive, and useless healthcare system in this country. My wife hired an attorney this afternoon to help us get started in becoming permanent European residents. We each have dual citizenship, although in a S. American country, but many E.U. countries are closing their doors, or at least making it a lot more difficult to emigrate.