Do Pluvicto patients live like those in the TV ad

Posted by soflada @soflada, Jun 9 11:51am

I'm a current Pluvicto patient who has been through Taxotere, 2 radiation sessions under a Varian Trubeam and have now had 2 of the 6 dose injections of Pluvicto. I see all the Pluvicto ads on golf and football broadcasts with all the "patients" looking and acting like they are top of the world. Yes, I know there is a proviso in the first few seconds of the ad that the people in the ad are actors. Still I would like to hope that there really is a world where patients who've been through all like me can truly be "normal." Ain't no way I'm even close to being that active. Can others hop in to let me know it is achievable?

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Profile picture for hector13 @hector13

I recently attended a Q&A session with urologists about prostate cancer, and one radiologist was praising the merits of Pluvicto as the best thing when hormones fail, and side-stepping my question about side effects. Are any of you fellows out there that are on Pluvicto having an easy time of it with few or no side effects? This would be important feedback for the next session I attend in person.

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I've been through 3 treatments with #4 coming up next week. Side effects are difficult if not impossible to nail on Pluvicto. Within the week after all the injections I've had effects I will lay on the isotope but can't verify. The shared effects are basically a totally rotten day. In two of them, I've had what I termed "flares" that required ramped up oxycodone to control. Can't remember what the third one was but it was a totally lost day. Never the same day or the same problems. But I'm sure they have all resulted from the isotope. And, as Jeff noted, Pluvicto is about the only thing that works after you've done all the others. Good luck and keep us posted.

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Pluvicto has worked well for myself
Halfway through
Dry mouth fatigue
Well worth it to be pain free!

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Profile picture for fatboy2003 @fatboy2003

Pluvicto has worked well for myself
Halfway through
Dry mouth fatigue
Well worth it to be pain free!

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Was cancer mets in bones only Is it killing it How many more months do they prject it will give you I start in Oct PSA 325

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Profile picture for melcanada @melcanada

Was cancer mets in bones only Is it killing it How many more months do they prject it will give you I start in Oct PSA 325

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One thing a lot of people don’t realize is that Pluvicto Only works real well for 1/3 of patients OK for 1/3 of patients and not at all for 1/3 of patients.

Besides that there is no fixed amount of time that it gives anybody, As usual with prostate cancer, everyone is different and everybody’s reaction to Pluvicto Is different.

If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto, to find out if you’ve got Genetic changes Due to the cancer. You should have already had a hereditary genetic test. You can even get one for free from prostatecancerpromise.org

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant. I don’t know if these are the only genetic changes that cause Pluvicto to work much better or more poorly, it is the latest list I have collected from people that have investigated this problem.

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Profile picture for melcanada @melcanada

Was cancer mets in bones only Is it killing it How many more months do they prject it will give you I start in Oct PSA 325

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Should feel better as soon as a few days
It seems everyone responds differently
Good luck!🙏🏽

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Profile picture for jeff Marchi @jeffmarc

One thing a lot of people don’t realize is that Pluvicto Only works real well for 1/3 of patients OK for 1/3 of patients and not at all for 1/3 of patients.

Besides that there is no fixed amount of time that it gives anybody, As usual with prostate cancer, everyone is different and everybody’s reaction to Pluvicto Is different.

If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto, to find out if you’ve got Genetic changes Due to the cancer. You should have already had a hereditary genetic test. You can even get one for free from prostatecancerpromise.org

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant. I don’t know if these are the only genetic changes that cause Pluvicto to work much better or more poorly, it is the latest list I have collected from people that have investigated this problem.

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How do you know about the genetic markers that work and the ones that are resistant. I don’t know much about Pluvicto but would I interested in your findings because my somatic test says I have PTEN and TP53.

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Profile picture for bka2 @bkandrew

How do you know about the genetic markers that work and the ones that are resistant. I don’t know much about Pluvicto but would I interested in your findings because my somatic test says I have PTEN and TP53.

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The Information was discussed in an ASCO Conference over a year ago. We had a review of the whole conference at ancan.org by Len who attended it.

If you’d like to hear some more information about it, come to an ancan.org Advanced prostate cancer weekly meeting. You can ask about it and they will give you some specific details about what’s going on.

If you just do this AI web search. “ pluvicto has issues with pten and tp53”
you will find information like this.

Studies have shown that patients with prostate cancer harboring mutations in genes like TP53, RB1, and PTEN experience worse overall survival compared to those without these mutations. These genetic changes can also correlate with poorer responses to various treatments, including Pluvicto.

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Thanks for responding. My husband was recently diagnosed with de novo oligometastatic PC. He had a tempus genetic test (somatic) and it came back with TP53 and PTEN. I guess it doesn’t look good for my husband. Very sad.

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