Hi, @lynnfardella We are all so very different. My neuropathy is idiopathic, meaning I don't know the cause. Ever since I began experiencing the numbness and tingling three years ago, I started on R-Alpha Lipoic Acid and Benfotiamine twice daily. I can't say for sure it has helped, but I'm hoping it might slow down the progression, so I continue it. A couple of years ago, my podiatrist prescribed the MetanX for me and I took that for a couple of months. When I went for my 6-month check with my GP, I asked him to check my vitamin and mineral levels along with my usual bloodwork. The results showed that my Vitamin B-6 was too high. I checked the ingredients for the MetanX and it was one of them.... and I have read so much about high levels of B6 causing neuropathy to worsen that I immediately stopped the MetanX. When my podiatrist prescribed it, she said her father had taken it for years and it helped his neuropathy symptoms. I'm glad it is also working for you.... but one of the hardest things to figure out with this malady is that it seems to come from so many different sources... and it also seems to affect all of us so differently. I have numbness in my feet and ankles... but no real pain, and for that I am grateful. But the numbness affects my balance, so I work constantly on that. At 74, I can no longer do what I did at 71... mainly because of concern about falling. I use a cane if I'm going to be walking a great distance and that has helped. I just seem to have less and less strength in my calves, so I can't stand still for long periods of time. As Bette Davis is famously quoted as saying, "Getting old is not for sissies." I'm finding that out with each passing year. Best wishes to you!! Mike