Talk with your doctors about side effect symptoms, and about your life goals. Don't skip Orgovyx. I'm 73, had PSA 6.4 last August, diagnosed Gleason 7 (3+4, 4+3) in November and also in iliac lymph nodes (N1M0) through December PSMA PET scan. I started Orgovyx Christmas Eve, then had 44 radiation treatments (26 general pelvis, 18 prostate-specific) during February-April. In May, blood test showed PSA .01 and Testosterone 0. I continue to have virtually every side effect listed on https://www.orgovyx.com/ . Dr.s seem only to be trained to attempt cures rather than focus on quality of life, and considering my overall condition and family history, I anticipate < 10 years, regardless, so I'll be having a conversation this fall about shortening or otherwise changing my treatment plan. I live in the Fort Worth area. If I can be helpful, let me know!