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Methotrexate side effects

Polymyalgia Rheumatica (PMR) | Last Active: Apr 26 8:54pm | Replies (49)

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I take the same weekly amt of methotrexate since May ( & am on prednisone since end of March now lowered to 5mgs). (I have prescription for folic acid as well to counter the methotrexate & take Alendronate to counter the bone wasting prednisone!!) I don’t have nausea but the morning poops are almost like diarrhea. It almost makes me hesitant to go to stretch class in the morning!!! But after the mornings things are ok. I didn’t know which drug was messing w/my intestines! At first I thought it was my decaf coffee so I went ahead & gave that up. Now I’m trying decaf green tea. But I don’t see a change! Gads. I have a Rheumy appt end of month w/labs to see how things are. I haven’t met w/him in 3 months.
I have to wonder what these drugs are doing to our insides? When (if) we get off this stuff do our inners repair themselves to some degree at least? Liver? Intestines? Skin? What else is affected?

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Replies to "I take the same weekly amt of methotrexate since May ( & am on prednisone since..."

I appreciate your comments on this. Sometimes I wonder if things will go back to "normal' after treatment. I'm 79 years old and have type 2 diabetes as well as other autoimmune issues. I try to keep my mind positive and listen to my body.

@kare1
Suggestion for the diarrhea after suffering for a few years. Increased my fiber with organic oatmeal. I order the microwavable cups online on Amazon. Easy prep in the morning. I also take Organic India psyllium capsules throughout the day. Two at a time with 8oz water. Never more than 4-5 capsules per day. Ease into it to give your bowels to adjust. Don’t take all at same time and remember drinking water is key. Took a couple of weeks to bulk stools up to normal. I am regular and have normal bm every day with no diarrhea anymore. Happy days!