I have had 4 Evenity treatments with minimal side effects ; some overall aches on the 7th day after injection but it went away in 24 hours. I do get more fatigued then usual at night ( 9pm) but I know my body is working hard to build bone. Medications effect us all differently - but they do effect us. I had a dickens of a time on Tymlos - weakness, stomach pain, inability to eat, heart palpatations- and I worked with an alternative doctor to solve these issues. Allpoathic docs dont have the insight or skill in this area and they need learn to be more supportive. As to your fatique, I would work with an alternative doc/ ayurvedic if possible. Maybe you need to reduce dose? Thats just a thought. I had to reduce tymlos it 1/8 dose and gradually move up. ALso, diet is crucial - do everythign you can to eat a supportive diet - include collagen ( fortibone) Sending postive energy and healing light.