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Folic Acid for peripheral neuropathy

Neuropathy | Last Active: Aug 24 8:19am | Replies (16)
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Profile picture for ohkay2 @ohkay2

Hi John,
When you say "methylfolate is the active form of folic acid", what does that mean?

I take 100mg folate daily.

I also take b-1 and b-6. I used to also take b-12 but my tests kept coming back showing my b-12 levels were too high.

Thanks!

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Replies to "Hi John, When you say "methylfolate is the active form of folic acid", what does that..."
John, Volunteer Mentor | @johnbishop | Aug 10 2:24pm

Hi @ohkay2, Here's an article/reference that explains the difference.

"Recent data suggest the need to distinguish between naturally occurring folates and folic acid (FA), terms often mistaken and used interchangeably, both by practitioners and consumers, causing considerable confusion.1
In particular, 5-Methyltetrahydrofolate [methylfolate, 5-MTHF, or (6S)-5-MTHF], has been evaluated as a better alternative to folic-acid supplementation.2-5 In this article, I endeavor to clearly identify the difference between folic acid and folate, pointing out why Quatrefolic, the 5-MTHF glucosamine salt from Gnosis by Lesaffre, is the ideal choice, suitable for anyone but in particular for those expressing methylenetetrahydrofolatereductase (MTHFR) polymorphism, which is approximately 40% of the global population.6-10"
-- Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health
https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/

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cit10jetjockey | @cit10jetjockey | Aug 11 7:07am

Ya gotta love the drug companies. Every drug production has side effects and in many cases PN was caused by cholesterol lowering drugs and that caused Type2 diabetes and that caused PN. I wonder how long the American Indians lived without drugs in their lives. I have a hunch that Buffalo meat and corn meals worked just fine.

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