I had problems with sleep quality, fatigue. exercise intolerance and I rated my quality of life as poor when Actemra was started. Those things didn't improve until I was off Prednisone. All those things gradually improved the longer I was able to stay off prednisone.

The most amazing thing to me was how many prescription medications I was apparently taking for Prednisone side effects. In addition to tapering off Prednisone ... I was able to discontinue at least 5 additional medications. My doctor says she likes to deprescribe medications better than prescribing medications. I have also stopped several over-the-counter medications.