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Anyone here after ADT undergone TRT

Prostate Cancer | Last Active: Aug 13, 2025 | Replies (21)

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Hi Rotate - Your "stop TRT and no ADT" situation sounds a little like mine.

I had been on TRT for 13 years and stopped it immediately after prostate biopsy confirmed Gleason 4+3. Total testosterone (TT) dropped from 900 to 50 in the following five weeks. No ADT at all. PSA also dropped from 8.1 to 1.9 during this five-week period. Radiation oncologist was okay with me passing on ADT since I was "close enough" to 20 ng/dL TT castrate level.

Started my five session SBRT radiation. Six weeks later my TT was 60 and PSA was 0.1.

Just curious -- How low did your TT and PSA go after you stopped TRT?

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Replies to "Hi Rotate - Your "stop TRT and no ADT" situation sounds a little like mine. I..."

I had eligard for a year with zeros for PSA and T levels we paused the eligard and for a year afterwards everything thing was still zeros and I was still anemic. After lots of discussion we started TRT but my testosterone levels were near 1000 at the start. Over a year I reduced the T amount I was taking until I was no more than 5% of what we started with. At this level my T blood levels were < 100 and still no PSA but good hemoglobin levels. My PSA began to wiggle a bit above zero, so we started ADT again. The whole time period of this was about 4 years. It was nice while it lasted. My T levels dropped back to zero, and I became anemic again and I got the pleasure of experiencing hot flashes once again. I’m now 10 years past initial diagnosis, and have just gone off eligard, but am continuing xtandi treatments of 2 pills per day. The xtandi started 2 years ago. I think there are better options than eligard, especially for long term use. There’s some debate between my urologist and I, but I think the eligard was a major factor in the decline of my kidney function, which I’m now battling along with everything else.