No, getting histotripsy doesnt depend on previous treatments, as I have had a lot of different modalities. I hope you find a center near you that does this procedure. One must continue systemic treatment since this procedure only works on the liver. I'm looking at clinical trials now that are a combo of the vaccine which no oncologist ever talks about anymore, and chemo (like fulfirnix) for the next step as an alternative to gem-Abraxane in case it's side efffets are too much for me or it doesn't work. I'm also inquiring with my oncologist about getting the stent put in early as a proactive procedure rather than a reactive procedure as even oncologist has indicated will be a thorn in my side as a result of the peritoneal nodules metastasizing to the large intestine as they will probably metastasize to. For people that shed a lot of CA19-9, I believe those blood tests should be taken every 2 weeks and it's how I determined the Naliri wasn't working for me. Praying for all of us!