I am in a clinical trial of no ADT, but I did have to cease TRT, leading to pretty low T, but not down to "castrate" level. I appreciate the article link above.

I had Gleason 9, but all other risk markers including DECIPHER were good. I had 70Gy 28 fraction proton radiation to the intact prostate and seminal vesicles.

But of course I wonder if I made the right decision - to join the trial. and thus avoid ADT And I do not eagerly await my first post radiation treatment checkup in a month. I have read that PSA trajectory after radiation of intact prostate can be way different than post RP.

I have most of the symptoms normally associated with ADT. My hot flashes seem to have faded, but night sweats are a real problem, ditto strength and energy, ED, etc.