I had my first Reclast infusion July 16th and did great. I attribute it to the knowledge I gained from posters here who emphasized super hydrating before, during, and after, as well as taking Tylenol and Claritin the day before, of, and after to minimize reactions. I was scared, I have to admit, because of all the negative comments. But the positive ones gave me the courage to go through with it, and I'm very glad I did. Good luck to you!