I was also told to take Claritin the day before the infusion (I did two days before), the day of, and the day after (I did two days after) to minimize a reaction. This was in addition to the Tylenol and extra hydration. It's sad that many doctors and infusion center personnel are not familiar with what the original protocol was during the Reclast clinical trials. At least give patients the information, and they can choose whether to follow the recommendations or not.