In addition it is the increase in beneficial gut flora which suppresses the transformation of metabolites into Testosterone. To me, this is the key to how it might prevent castrate resistance.
If your body is producing its own steady stream of T in the gut - even though you are on ADT drugs which suppress different metabolic pathways (luteinizing hormone), you really haven’t been chemically castrated, have you? The PCa cells are still getting fed T. So perhaps castrate resistance is a misnomer and the reasons lutamides work better is because they target the T receptor sites and not the production of T itself. Just a thought…