By IRE do you mean the NanoKnife procedure? NanoKnife is an excellent procedure for focal therapy, and one I considered. But I grew an additional tumor and figured I would do a full ablation.

As for the biopsy, try to get a Transperineal Prostate Biopsy. You will be sedated, the entire prostate can be sampled; there is no rectal damage, no rectal bleeding, no rectal infection, and nearly no chance of a prostate infection from the procedure. Virtually no pain afterwards, you will have blood in your semen for several weeks, and probably no blood in your urine.