I’ve been on three different antidepressants throughout my adult life. All episodes have been due to health issues and one job issue. It’s really important to talk to your doctor before going off any antidepressants. It’s not an easy transition for most. I’ve been on Prozac, Lexapro, and now Pristiq. Prozac was a long time ago, and I believe it was a slow process. I tried to go down slowly on Lexapro but had a relapse and was switched to Pristiq. I think I’ll need to be on an antidepressant for the rest of my life. I’ve heard horrid stories about withdrawal from Pristiq. Again, please talk to your doctor!!! They should be able to help you wean off the medicine.