Hi, It's my first time commenting on here, and I wanted to share with you specifically. Dx in March 2025 with MAC and mild BE, 64 yrs young, and daily runner. Started on all Big 3 immediately and after 4 months, ID doc started Arikayce. With the exception of very slight fatigue on some days, I have had zero side effects from these four antibiotics. It took me 1 week to make med schedule fit my daily routine, not the other way around!!! After looking at other posts and realizing there's way more to be hopeful for than despair over, my initial fears of the unknown were mitigated. Though the daily regimen of meds/boiling water/airway clearance is a pain in the arse, I have chosen to not let MAC interfere with my schedule of enjoying my life in every aspect. Good luck to you in this new adventure. Terri