← Return to Turkey Tail mushrooms and FOS. Anyone else here use these?

Discussion
Comment receiving replies
Profile picture for ededed @ededed

Yes, but not the two polysaccharides (PSP and K) that are contained in turkey tail that have been shown to attack prostate cancer stem cells. Other foods that have anti-cancer effects are tomatoes and broccoli which both have more effect when eaten after they are cooked.
From: https://pmc.ncbi.nlm.nih.gov/articles/PMC8542389/
White button mushroom (WBM) (Agaricus bisporus) is a potential prostate cancer (PCa) chemopreventative and therapeutic agent. Our clinical phase I trial of WBM powder in patients with biochemically recurrent PCa indicated that WBM intake reduced the circulating levels of prostate-specific antigen (PSA). We hypothesized that WBM exerts its effects on PCa through the androgen receptor (AR) signaling axis. Therefore, we conducted a reverse translational study with androgen-dependent PCa cell lines (LNCaP and VCaP) and patient-derived-xenografts (PDX) from a prostate tumor (TM00298). In both LNCaP and VCaP cells, western blots and qRT-PCR assays indicated that WBM extract (6~30 mg/mL) suppressed DHT-induced PSA expression and cell proliferation in a dose-dependent manner. Immunofluorescence analysis of AR revealed that WBM extract interrupted the AR nuclear-cytoplasmic distribution. PSA promotor-luciferase assay suggested that WBM extract inhibited DHT-induced luciferase activity. RNA-Seq on WBM-treated LNCaP cells confirmed that WBM treatment suppressed the androgen response pathways and cell-cycle control pathways. Our PDX showed that oral intake of WBM extract (200 mg/kg/day) suppressed tumor growth and decreased PSA levels in both tumors and serum. In the present study, we also identified a conjugated linoleic acid isomer (CLA-9Z11E) as a strong AR antagonist by performing LanthaScreen™ TR-FRET AR Coactivator Interaction Assays. The inhibitory effect of CLA-9Z11E (IC50: 350 nM) was nearly two times stronger than the known AR antagonist, cyproterone acetate (IC50: 672 nM). The information gained from this study improves the overall understanding of how WBM may contribute to the prevention and treatment of PCa.

Jump to this post


Replies to "Yes, but not the two polysaccharides (PSP and K) that are contained in turkey tail that..."

Been taking WBM powder over two years now in my am Hot Green tea. I m off ADT since last January 2025. ADT substance still in my body. However my PSA is less than .01 for 30 months now. FYI only. Thank you. Bruce