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Replies to "Perineural invasion (PNI) is pretty common, it is really not a big factor in your cancer..."
Prostate Cancer | Last Active: Aug 6, 2025 | Replies (15)
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Perineural invasion (PNI) is pretty common, it is really not a big factor in your cancer risk. I Noticed a few months ago that my biopsy from 15 years ago had PNI. Found the same thing in a lot of other people’s biopsies, and it was not a factor in their future.
What’s missing in this information is what percentage of that 3+4 had cancer and what percentage of it was a 4? If it comes down to five or 10%, then active surveillance still might make sense.
Replies to "Perineural invasion (PNI) is pretty common, it is really not a big factor in your cancer..."
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"Prostatic adenocarcinoma, Gleason score 3+4=7 (grade group 2, pattern 4=5%), involving 1 of 1 core (5 mm, 30%)"
I read that PNI indicates a pathway for cancer to spread out of the gland.
When we just had the biopsy report more active surveillance seemed like the way to go but then the .6 Decipher score muddied the waters. That indicates I am on the very high end of intermediate risk aka low end of high risk.