I am in a similar situation but my Signatera has been negative and normal CEA. Scans showed 10mm nodule in lung and a few smaller ones. Pet Scan could not rule out inflammation on the 10 mm, all other nodules were benign. My oncologist says he’s 95% certain it’s cancerous. I am going to see my radiologist for this one and just monitor regularly for any others. I had recent Covid and the flu prior to this scan so am not certain I am in agreement with my oncologist. I do not like that he is pushing systematic chemo again for one lung nodule. I am against more chemo as recent studies are coming out that it may very well cause recurrence of more aggressive cancer. I am all about giving my body time to heal and do its job. Chemotherapy will cause my body to have to fight harder. I am relying on God these days more than ever as he created my body and he is the one who knows how to heal it.