I too met with Dr Pow-Sang at Moffitt to discuss focal options for my 3+4=7 in one core of MRI Guided 13 core biopsy. My PSA was 4.5 in February ‘25, MRI in March showed PIRAD 5 lesion inside prostate only which measured 2.2cm, and targeted biopsy in April ‘25 confirmed it. I Had CT with contrast and PSMA PET showing the cancer was contained in gland. I was interested in IRE as well. Anyways Dr Pow-Sang told me my lesson was too large for focal therapy and if they did one he said the chances of reoccurrence would be 50/50. He also said any focal therapy has a much higher chance of coming back at some time, and also requires lots of follow up like 3 mos PSA blood tests (not bad) and 6 mos biopsies. He said it would be like kicking the can down the road in his words, at least in my case. He suggested whole gland radiation treatment for me. Another interesting fact just happened. My Onocolgist ordered another PSA blood test since my last was in February ‘25 and it went down significantly!?!?! I was a 4.5 in February and the other day (7/31) I am a 3.2?!?? That’s almost a 30% reduction? Has anyone heard of this happening before? All my PSA tests have been done at Quest so the same lab. That just seams like a large reduction for a recently diagnosed cancer through both MRI and biopsy.