Hi. I also take the big three. I take them after I’ve eaten. Azithromycin by 8:30am after breakfast. Have a late morning probiotic yogurt snack (helps any nausea immediately). Then Rifampin after lunch at least four hours after the first med. late afternoon snack then dinner by 6:30pm and the ethambutol after dinner. My pharmacist recommended spacing the meds at least four hours apart. It works for me so far. I’ve only just begun so 🙏🏻