At least a dozen people on the weekly advanced prostate cancer Ancan.org group are on it and almost all are castrate resistant.
Tell your doctor you want nubeqa instead of Xtandi. The doctor knows you know the difference maybe you can get them to give you the drug with the lesser side effects.
Pluvicto sounds like a good chance to get the cancer controlled.
Exactly Originally, I think, the -lutamides (and Abiraterone) were intended primarily for metastatic castrate-resistant prostate cancer, following the older approach of gradual escalation of treatment (start on ADT, and when that stops working, add a reception inhibitor, then chemo, etc., step by step).
But then a series of trials like TITAN and STAMPEDE demonstrated that it's far more effective to hit the cancer hard up right away, while it's still castrate-sensitive, so they extended some of those second-line treatments to mCSPC as well.
Why not go with Orgovyx its just a pill and as effective as Lupron. I started taking Orgovyx 06/01/25 PSA test in 07/05/25 (< .01 undetectable) down from 1.04 in 06/01/25.
Why not go with Orgovyx its just a pill and as effective as Lupron. I started taking Orgovyx 06/01/25 PSA test in 07/05/25 (< .01 undetectable) down from 1.04 in 06/01/25.
In some ways, Orgovyx is more effective than Lupron — as a GnRH agonist, Lupron creates an initial testosterone surge that can trigger more even cancer spread before the testosterone suppression starts. As a GnRH antagonist, Orgovyx starts working immediately, which is crucial if your cancer is aggressive.
Note that you can prevent Lupron's initial testosterone surge using bicalutamide or flutamide, but it still doesn't start actually working to *suppress* testosterone until the surge would have been finished, so it's not the best initial treatment for urgent, fast moving cancer like mine. That's why my medical team started me on Firmagon (a GnRH antagonist like Orgovyx, but as an injection) back in 2021, when Orgovyx wasn't approved yet in Canada.
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Exactly Originally, I think, the -lutamides (and Abiraterone) were intended primarily for metastatic castrate-resistant prostate cancer, following the older approach of gradual escalation of treatment (start on ADT, and when that stops working, add a reception inhibitor, then chemo, etc., step by step).
But then a series of trials like TITAN and STAMPEDE demonstrated that it's far more effective to hit the cancer hard up right away, while it's still castrate-sensitive, so they extended some of those second-line treatments to mCSPC as well.
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2 ReactionsWhy not go with Orgovyx its just a pill and as effective as Lupron. I started taking Orgovyx 06/01/25 PSA test in 07/05/25 (< .01 undetectable) down from 1.04 in 06/01/25.
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1 ReactionIn some ways, Orgovyx is more effective than Lupron — as a GnRH agonist, Lupron creates an initial testosterone surge that can trigger more even cancer spread before the testosterone suppression starts. As a GnRH antagonist, Orgovyx starts working immediately, which is crucial if your cancer is aggressive.
Note that you can prevent Lupron's initial testosterone surge using bicalutamide or flutamide, but it still doesn't start actually working to *suppress* testosterone until the surge would have been finished, so it's not the best initial treatment for urgent, fast moving cancer like mine. That's why my medical team started me on Firmagon (a GnRH antagonist like Orgovyx, but as an injection) back in 2021, when Orgovyx wasn't approved yet in Canada.
I get mine (6mo.) at the top of my buttock. Painless, unlike a stomach injection, which seemed to burn. I never had it in the arm.