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Let's walk it back to the basics.

Most prostate cancer needs testosterone as a signal to reproduce, at least initially (sometimes it evolves to ability to reproduce without it; that's called "castrate-resistant prostate cancer").

Reducing testosterone, either through an orchiectomy (physical castration) or androgen-deprivation therapy (ADT, aka "chemical castration") is a first line of defense to slow or stop prostate cancer spread.

Low testosterone — however triggered — comes with a range of potential undesirable side-effects, including bone and muscle density loss, hot flushes, low energy, mood swings, weight gain, reduction in sex drive, gynocomastia (breast development), and elevated risks of diabetes, heart disease, and stroke. Many of these are similar to menopause symptoms in women, and not all of them will happen to every patient.

Traditionally, ADT has been administered by an injection every 1–3 months, which can sometimes cause short-term acute symptoms (swelling, rashes, muscle ache, flu-like symptoms) in addition to the longer-term, chronic testosterone-deprivation symptoms I listed above.

Orgovyx has all the same long-term chronic side-effects as the other ADT medications, but comes in a daily microdose as a pill, so it doesn't cause the acute symptoms that injections do, and leaves your body more quickly when you stop. And unlike some injectibles like Lupron, it starts working right away, without an initial testosterone surge that can temporarily accelerate cancer spread.

That's why Orgovyx is considered the "latest and greatest" as far as ADT is concerned, but ADT in general is not the only approach for treating prostate cancer. There are many other treatments they can add on top of it, depending on the patient's cancer status, age, health, genetic background, and (most importantly) personal choices.

I hope this helps to set some context.

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Replies to "Let's walk it back to the basics. Most prostate cancer needs testosterone as a signal to..."

Depending on his numbers he might use Oorgovyx stand alone and intermittently without radiation or surgery.

My husband had a hormone injection about 10 weeks ago. As well, he takes abiraterone on a daily basis. The medical oncologist has him booked for another hormone injection (elgard, I think) in a couple of months. She has indicated that my husband will probably be hormone therapy for the rest of his life. I hate that idea. His libido is negligent, and the reason I worry about that is the prospect of atrophy. IF there is any chance that the testosterone comes back, atrophy could prevent sexual activity. And, of course, there are so many other side effects, muscle and bone loss, etc. I am hoping to hear that hormone therapy is not a lifetime prospect. My husband has metastasis in about 5 lymph nodes. ALSO, I asked the oncologist if we will get another PSMA in order to see what the result of radiation and hormone therapy has been. He said no PSMA until my husband has had hormone therapy for 2 years. I don't understand that. They didn't even provide the original PSMA for us; we found a private company and paid $3,200 for it. I am willing to pay again, in order to determine the results of the present treatment. Does anyone have comments or ideas on that?