Thank you for responding. Yes, my doc has me on a two week med holiday and then reduce dosage to 5mg a day. Already my energy levels are improved and skin cleared up, but it’s been a week off med and no improvement in ankle. Actually I have a new swollen spot on my foot. I’ve got myself all worried that it’s a new met to the bone in foot as I’ve read this upon researching it a little. I should know better than to Dr. Google at this point.😹 While I’m awaiting MRI and ortho consult I need to stick to asking people who are going through same disease. Thanks again and I hope you are having a peaceful evening.🤗🌺